Associate Professor Paul Anderson 

Musculoskeletal Biology Research Laboratory - SA Pathology
: Office +61882223244; Fax +61882223518

I am a research scientist located in Chemical Pathology, SA Pathology and my major focus is characterising dietary and hormonal factors that influence bone structure and strength particularly as related to osteoporosis. In particular, I have recently indentified novel roles for vitamin D on the regulation of bone cell proliferation and maturation as well as resorptive activity.I am currently studying animal models of vitamin D depletion, knockouts and transgenics to study vitamin D metabolism and activity at the bone cell level. My work integrates biochemical, hormonal, and dietary interactions with quantification of skeletal structure, strength and bone cell activities including molecular signalling. My current studies quantifying the effects of direct and indirect activities of vitamin D on bone are focussed on providing scientific evidence for how vitamin D supplementation reduces the incidence of hip fracture in the elderly.

Musculoskeletal Biology Research

Chemical Pathology, IMVS

• Calcium, phosphate and bone physiology
• Renal physiology

Australian and New Zealand Bone and Mineral Society

American Society for Bone and Mineral Research

Australian Society for Medical Research

Molecular and Experimental Pathology Society of Australia

NHMRC R.D. Wright Fellow

PhD (Physiology)

BSc (Honours)

• Osteoporosis and Metabolic Bone Diseases
• Vitamin D Metabolism and Activities
• Calcium Physiology

Extracellular phosphate modulates the effect of 1a,25-dihydroxy vitamin D(3) (1,25D) on osteocyte like cells. Ito N, Findlay DM, Anderson PH, Bonewald LF, Atkins GJ. J Steroid Biochem Mol Biol. 2012 Oct 9. pii: S0960-0760(12)00197-5. doi: 10.1016/j.jsbmb.2012.09.029. [Epub ahead of print] PMID: 23064198 [PubMed - as supplied by publisher] Related citations

Macsai CE, Derrick Roberts AL, Ding X, Zarrinkalam KH, McIntyre C, Anderson PH, Anson DS, Byers S. Skeletal response to lentiviral mediated gene therapy in a mouse model of MPS VII. Molecular Genetics and Metabolism. 2012 [accepted 31st March]

Modulation of osteoclastic migration by metabolism of 25(OH)-vitamin D(3). Kogawa M, Findlay DM, Anderson PH, Atkins GJ. J Steroid Biochem Mol Biol. 2012 Sep 16.

Turner AG, Anderson PH, Morris HA, Vitamin D and Bone Health. Scandanavian Journal of Clinical and Laboratory Investigation. 2012 [Invited review, accepted 5th Jan]

The pleiotropic effects of vitamin D in bone. Anderson PH, Lam NN, Turner AG, Davey RA, Kogawa M, Atkins GJ, Morris HA. J Steroid Biochem Mol Biol. 2012 Sep 5. pii: S0960-0760(12)00151-3.

Anderson PH, Tuner AG, Morris, HA Vitamin D actions to regulate calcium and skeletal homeostasis. Clinical Biochemistry. 2012 [accepted 25th Feb].

Vitamin D and bone health. Turner AG, Anderson PH, Morris HA. Scand J Clin Lab Invest Suppl. 2012 Apr;243:65-72. Review. PMID: 22536765 [PubMed - indexed for MEDLINE] Related citations

Morris HA, Turner AG, Anderson PH. Vitamin-D regulation of bone mineralization and remodelling during growth. Front Biosci (Elite Ed). 2012 Jan 1;4:677-89.

Anderson PH, Atkins GJ, Turner AG, Morris HA. Vitamin D Metabolism within Bone Cells: Effects on Bone Structure and Strength. Molecular and Cellular Endocrinology 2011 [Invited Review, in preparation]

Davey RA, Clarke MV, Sastra S, Skinner JP, Chiang C, Anderson PH, Zajac JD. Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual. Transgenic Res. 2011 Dec 13.

Morris HA and Anderson PH. Autocrine and Paracrine Actions of Vitamin D. Clinical Biochemistry Reviews. 2010 [accepted, 12th Sept 2010].

Morris HA, Anderson PH. Vitamin D metabolism and biological activities. Mol Cell Endocrinol. 2011 Dec 5;347(1-2):1-2. Epub 2011 Jun 25

Morris HA, O’Loughlin PD and Anderson PH. Experimental Evidence for the Effects of Calcium and Vitamin D on Bone: A Review. Nutrients. 2010 [accepted, 11th Sept 2010]

Moghaddami M, Mayrhofer G, Anderson PH, Morris HA, Van Der Hoek M, Cleland LG Efficacy and mechanisms of action of vitamin D in experimental polyarthritis. Immunol Cell Biol. [published online 29 Mar 2011]

Yu C, Fedoric B, Anderson PH, Lopez AF, Grimbaldeston, MA. Vitamin D3 – Mast Cells: a new axis regulating protection from UVB-induced skin damage. Journal of Biochemistry and Cell Biology 2010 [Epub ahead of print] [Invited Review]

Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ. Osteoclastic metabolism of 25(OH)D3: a potential mechanism for optimization of bone resorption. Endocrinology 2010 151(10):4613-25

Anderson PH, Iida S, Tyson JHT, Turner AG, Morris HA. Bone CYP27B1 gene expression is increased with high dietary calcium and in mineralising osteoblasts. Journal of Steroid Biochemistry and Molecular Biology 2010 121:71-75

Kumar R, Iachini DN, Neilsen PM, Kaplan J, Michalakas J, Anderson PH, May BK, Morris HA, Callen DF. Systematic characterisation of the rat and human CYP24A1 promoter. Molecular and Cellular Endocrinology. 2010 325: 46-53.

Anderson PH, Lee AM, Anderson SM, Sawyer RK, O’Loughlin PD, Morris HA. The effect of dietary calcium on 1,25(OH)2D3 synthesis and sparing of serum 25D levels. Journal of Steroid Biochemistry and Molecular Biology 2010 121: 288-92

Lee AM, Anderson PH, Sawyer RK, Moore AJ, Forwood M, Steck R, Morris HA, O‘Loughlin PD. Discordant effects of vitamin D deficiency in trabecular and cortical bone architecture and strength in growing rodents. Journal of Steroid Biochemistry and Molecular Biology 2010 121:284-7

Kogawa M, Anderson PH, Findlay DM, Morris HA, Atkins, GJ 2009 The metabolism of 25(OH)-vitamin D3 by osteoclasts and their precursors regulates the differentiation of osteoclasts. Journal of Steroid Biochemistry and Molecular Biology 2010 121:277-280

Turner AG, Dwivedi PP, Anderson PH, May BK, Morris HA. Regulation of the 5'-flanking region of the human CYP27B1 gene in osteoblast cells. Molecular and Cellular Endocrinology. 2009 Nov 13; 311(1-2):55-61.

Chiang C, Chiu M, Moore AJ, Anderson PH, Ghasem-Zadeh A, McManusm JF, Ma C, Seeman E, Clemens TL, Morris HA, Zajac JD, Davey RA. Mineralization and bone resorption are regulated by the androgen receptor in male mice. Journal of Bone and Mineral Research 2009 24:621-31

Anderson PH & Atkins GJ. 2008 The skeleton as an intracrine organ for vitamin D metabolism. Molecular Aspects of Medicine 29(6):397-406. [Invited Review]

Anderson PH, Sawyer RK, Moore AJ, May BK, O'Loughlin PD, Morris HA. Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model. Journal of Bone and Mineral Research 2008 23:1789-97.

Davey RA, Turner A, McManus JF, Chiu M, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C, Glatt V, MacLean H, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD. The Calcitonin Receptor Plays a Physiological Role to Protect Against Hypercalcemia in Mice. Journal of Bone and Mineral Research 2008 23:1182-93.

Anderson PH, Hendrix I, Sawyer RK, Zarrinkalam R, Manavis J, Sarvestani GT, May BK and Morris HA. 2008 Co-expression of CYP27B1 enzyme with the 1.5 kb CYP27B1 promoter-luciferase transgene in the mouse. Molecular and Cellular Endocrinology 283: 1-9.

Tan J, Dwivedi PP, Anderson PH, Nutchey B, O’Loughlin PD, Morris HA, May BK, Ferrante A, Hii CST. Anti-neoplastic agents target the 25-hydroxyvitamin D3 24-hydroxylase mRNA for degradation: implications in anti-cancer activity. Molecular Cancer Therapeutics 2008 6: 3131-3138.

Anderson PH, Hendrix I, Sawyer RK, Zarrinkalam RM, Manavis J, Sarvestani GT, May BK, Morris HA. Co-expression of the CYP27B1 and the CYP27B1 promoter-luciferase transgene in the mouse: tissue specific regulation and cellular localization. Molecular and Cellular Endocrinology. 2008 285: 1-9

Atkins GJ, Anderson PH, Findlay DM, Welldon KJ, Vincent T, Zannettino ACW, O’Loughlin PD, Morris HA 2007 Autocrine activities of 1,25 dihydroxyvitamin D3 in human osteoblast-like cells: implications for bone cell biology. Bone 40: 1517-1528.

Anderson PH, Sawyer RK, O’Loughlin PD, May BK, Morris HA 25-Hydroxyvitamin D Requirement for Maintaining Skeletal Health Utilising a Sprague-Dawley Rat Model. Journal of Steroid Biochemistry and Molecular Biology 2007 103: 592-595.

Anderson PH, Atkins GJ, Findlay DM, O’Loughlin PD, Welldon K, Vincent C, Morris HA 2007 RNAi-mediated silencing of CYP27B1 abrogates vitamin D-mediated osteocalcin in human osteosarcoma cells (HOS). J Steroid Biocchem Molec Biol 103: 601-605.

Dwivedi PP, Anderson PH, Tilley WD, May BK, Morris HA 2007 Role of oncoprotein Growth Factor Independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): A comparative analysis in human prostate cancer and kidney cells. J Steroid Biochem Mol Biol 103:742-746.

Dwivedi PP, Anderson PH, Omdahl JL, Grimes HL, Morris HA, May BK 2005 Identification of growth factor independent-1 (GFI1) as a repressor of 25-Hydroxyvitamin D 1-a hydroxylase (CYP27B1) gene expression in human prostate cancer cells. Endocrine-Related Cancer 12: 351-65.

Anderson PH, O’Loughlin PD, May BK, Morris HA 2005 Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels. Bone 36: 654-62.

Hendrix I, Anderson PH, Omdahl, JL, May BK, Morris HA Response of the 5’-flanking region of the human 25-hydroxyvitamin D 1a-hydroxylase gene to physiological stimuli using a transgenic mouse model. Journal of Molecular Endocrinology 2005 34: 237-245.

Anderson PH, O’Loughlin PD, May BK, Morris HA Determinants of circulating 1,25-dihydroxyvitamin D3 levels: the role of renal synthesis and catabolism of vitamin D. Journal of Steroid Biochemistry and Molecular Biology 2004 89: 111–113.

Hendrix I, Anderson PH, May BK, Morris HA Regulation of gene expression by the CYP27B1 promoter—study of a transgenic mouse model. Journal of Steroid Biochemistry and Molecular Biology 2004 89: 139–142.

Anderson PH, O’Loughlin PD, May BK, Morris HA Quantification of CYP27B1, CYP24 and Vitamin D receptor mRNA levels in kidney using real-time reverse transcriptase-polymerase chain reaction. Journal of Molecular Endocrinology 2003 31:123-132.

Anderson PH, May BK, Morris HA Vitamin D metabolism: New concepts and clinical implications. Clinical Biochemist Reviews 2003 24:13-26. (Invited review).

Anderson PH, Atkins GJ, Findlay DM, Morris HA. 'Target Genes: Bone Proteins' in: Vitamin D, 3rd Edition, Eds Feldman D, Pike W, Glorieux FH, Elsevier Academic Press, [In Press] 2010.

Anderson PH, Atkins GJ, Findlay DM, Morris HA. 'Target Genes: Bone Proteins' in: Vitamin D, 2nd Edition, Eds Feldman D, Pike W, Glorieux FH, Elsevier Academic Press, pp 711-72, 2005.

Anderson PH, May BK and Morris HA Effects of oestradiol and calcitriol on intestinal mRNA levels of Vitamin D receptor and genes controlling calcium transport. In: Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application, page 757-758 Editors: AW Norman, R Bouillon and M Thomasset. Walter de Gruyter, New York 1997

I am able to provide media comment in the following areas of expertise:

Discipline: Medical Sciences

• Vitamin D biology
• Skeletal health