Dr Matt Sykes

Matt completed a Bachelor of Science honours degree in chemistry at Flinders University and subsequently completed a PhD at the same institution working in the field of molecular property prediction with Dr. Errol McCoy. After completing his PhD Matt worked as a Postdoctoral Research Associate at the University of Sheffield in the UK and at Astra Zeneca pharmaceuticals in Alderley Edge, Cheshire with Professor Barry Pickup and Dr Andrew Grant. This work centred around developing computational tools to expedite the drug development process, in particular looking at areas related to solvation of small molecules and proteins. More recently Matt has been working as a Research Fellow in the Department of Clinical Pharmacology at Flinders University with Professor John Miners, looking at computer-based methods for screening, identification and analysis of molecules of importance to human hepatic drug metabolism.

• Course Coordinator, Chemistry 100
• Course Coordinator, Pharmaceutical Analysis 1

Royal Australian Chemical Institute

National Tertiary Education Union

Adelaide Pharmacology Group

Guest editor of special issue of Current Topics in Medicinal Chemistry. The issue will focus on the medicinal chemistry of the cytochrome P450's.

B.Sc.(hons.) PhD MRACI (C.Chem.)

B.Sc. Chemistry , First Class Honours, Flinders University (1996).

PhD in Computational Chemistry, Flinders University (2000).

MRACI (C.Chem.), Corporate Member of the Royal Australian Chemical Institute (2001).

• Cytochrome P450 structure-metabolism relationships
• Molecular property prediction
• Drug-membrane interactions

Burdon, K.P.; Sharma, S.; Danoy, P.A.; Martin, S.; Pryce, K.; Dave, A.; Leo, P.; Hadler, J.; Hewitt, A.W.; Sykes, M.J.; Miners, J.O.; Mackey, D.A.; Mitchell, P.; Brown, M.A.; Craig, J.E. A genome-wide association study for susceptibility loci for pseudoexfoliation syndrome, Journal of Medical Genetics, 2009, submitted.

Nussio, M.R.; Voelcker, N.H.; Miners, J.O.; Lewis, B.C.; Sykes, M.J.; Shapter, J.G. AFM Study of the Interaction of Cytochrome P450 2C9 with Phospholipid Bilayers, Chemistry and Physics of Lipids, 2009, accepted.

Nussio, M.R.; Sykes, M.J.; Miners, J.O.; Shapter, J.G. Kinetics of membrane disruption due to drug interactions of chlorpromazine hydrochloride. Langmuir, 2009, v25(2), 1086-1090.

Nussio, M.R.; Voelcker, N.H.; Sykes, M.J.; McInnes, S.J.P.; Gibson, C.T.; Lowe, R.D.; Miners, J.O.; Shapter, J.G. Lateral heterogeneities in supported bilayers from pure and mixed phosphatidylethanolamine demonstrating hydrogen bonding capacity. Biointerphases, 2008, v3(4), 96-104.

Sykes, M.J.; McKinnon, R.A.; Miners, J.O. Prediction of Metabolism by Cytochrome P450 2C9: Alignment and Docking Studies of a Validated Database of Substrates. Journal of Medicinal Chemistry, 2008, v51(4), 780-791.

Nussio, M.R.; Liddell, M.; Sykes, M.J.; Miners, J.O.; Shapter, J.G. Dynamics of phospholipid membrane growth and drug-membrane interactions probed by atomic force microscopy (AFM). Journal of Scanning Probe Microscopy, 2007, v2(1-2), 41-45.

Grant, J.A.; Pickup, B.T.; Sykes, M.J.; Kitchen, C.A.; Nicholls, A. The Gaussian Generalized Born model: application to small molecules. Physical Chemistry Chemical Physics, 2007, v9(35), 4913-4922.

Grant, J.A.; Pickup, B.T.; Sykes, M.J.; Kitchen, C.A.; Nicholls, A. A simple formula for dielectric polarisation energies: The Sheffield Solvation Model. Chemical Physics Letters, 2007, v441(1-3), 163-166.

Nussio, M.R.; Sykes, M.J.; Miners, J.O.; Shapter, J.G. Characterisation of the binding of cationic amphiphilic drugs to phospholipid bilayers using surface plasmon resonance. ChemMedChem, 2007, v2(3), 366-373.

Knights, K.M.; Sykes, M.J.; Miners, J.O. Amino acid conjugation: contribution to the metabolism and toxicity of xenobiotic carboxylic acids. Expert Opinion On Drug Metabolism & Toxicology, 2007, v3(2), 159-168.

Sykes, M.J.; Sorich, M.J.; Miners, J.O. Molecular modeling approaches for the prediction of the nonspecific binding of drugs to hepatic microsomes. Journal of Chemical Information and Modeling, 2006, v46(6), 2661-2673.

Phillips T.; Haq I.; Meijer A.J.H.M.; Adams H.; Soutar I.; Swanson L.; Sykes M.J.; Thomas J.A. DNA binding of an organic dppz-based intercalator. Biochemistry, 2004, v43(43), 13657-13665.

McCoy, E.F.; Sykes, M.J. Quantum-mechanical QSAR/QSPR descriptors from momentum-space wave functions. Journal of Chemical Information and Computer Sciences, 2003, v43(2), 545-553.

McCoy, E.F.; Sykes, M.J. The estimation of molecular properties using momentum-space wavefunctions. Chemical Physics Letters, 1999, v313(3-4), 707-712.

McCoy, E.F.; Sykes, M.J. A method for calculating the equilibrium thermodynamic properties of gas reaction mixtures. Australian Journal of Chemistry, 1998, v51(1), 55-60.