Dr Maurizio Costabile

Hello and welcome to Dr Maurizio Costabile's homepage at the University of South Australia.

I am a senior lecturer in the School of Pharmacy and Medical Sciences at the University of South Australia and Senior medical scientist at the Women's and Children's Hospital, Department of Immunopathology.

At the University of South Australia, I can be contacted on 8302 2176, while at the Women's and Children's Hospital, I can be contacted on 8161 6293.

I am the Program Director for the Medical and Pharmaceutical Biotechnology Program. I can be contacted for all matters relating to this program.

Immunology Links on the WWW

The Journal of Immunology Homepage

The Immunology Link Homepage

Antibody structure

ELISA assay

Entrez-PubMed

Cytokines resources

• Immunology

  Biochemistry

  Molecular Pathogenesis of disease

  Primary Immunodeficiency diseases

I teach the following courses

BIOL 2014	Biochemistry N 200
BIOL 2017	Biochemistry P 200
BIOL 2037	Immunology N 201
BIOL 2030	Microbiology and Immunology P 201
MEDI 2004	Microbiology and Pathophysiology PO 201
MEDI 3010	Honours Laboratory Medicine 301A
MEDI 3011	Honours Laboratory Medicine 301B
MEDI 4007	Honours Laboratory Medicine 400A
MEDI 4008	Honours Laboratory Medicine 400B

Professional associations

1994 Bachelor of Science, Flinders University

• Immunology of T lymphocytes

  Molecular diagnosis of Immunodeficiency diseases

  Cancer immunology

Mukaro VR, Costabile M, Murphy KJ, Hii CS, Howe PR, Ferrante A. 2008. Leukocyte numbers and function in subjects eating n-3 enriched foods: selective depression of natural killer cell levels. Arthritis Res Ther.10:R57.

Moghaddami N, Irvine J, Gao X, Grover PK, Costabile M, Hii CS, Ferrante A. 2007. Novel action of n-3 polyunsaturated fatty acids: inhibition of arachidonic acid-induced increase in tumor necrosis factor receptor expression on neutrophils and a role for proteases. Arthritis Rheum. 56(3):799-808.

Chatziandreou I, Gilmour KC, McNicol AM, Costabile M, Sinclair J, Cubitt D, Campbell JD, Kinnon C, Qasim W, Gaspar HB. 2007. Capture and generation of adenovirus specific T cells for adoptive immunotherapy. Br J Haematol. 136(1):117-26.

Costabile M, Quach A, Ferrante A. 2006. Molecular approaches in the diagnosis of primary immunodeficiency diseases. Hum Mutat. 27(12):1163-73.

Costabile M, Hii CS, Melino M, Easton C, Ferrante A. 2005. The immunomodulatory effects of novel beta-oxa, beta-thia, and gamma-thia polyunsaturated fatty acids on human T lymphocyte proliferation, cytokine production, and activation of protein kinase C and MAPKs. Journal of Immunology. 174(1):233-43.

Moghaddami N, Costabile M, Grover PK, Jersmann HPA, Huang ZH, Hii CST, and Ferrante A. 2003. Unique Effect of Arachidonic Acid on Human Neutrophil TNF Receptor Expression: Up-Regulation Involving Protein Kinase C, Extracellular Signal-Regulated Kinase, and Phospholipase A2. J. Immunol. 171:2616-2624.

Hii CS, Costabile M, Mayne GC, Der CJ, Murray AW, Ferrante A.2003. Selective deficiency in protein kinase C isoenzyme expression and inadequacy in mitogen-activated protein kinase activation in cord blood T cells. Biochem J. 370:497-503.

Costabile M, Hii, CST, Robinson, BS, Easton, C, Pitt, M, Rathjen, DA, Ferrante A. 2001. Inhibition of lymphocyte proliferation and cytokine production by a novel engineered polyunsaturated fatty acid. Journal of Immunology. 167(7):3980-3987.

Li YQ, Hii CS, Costabile M, Goh D, Der CJ, Ferrante A. 1999. Regulation of lymphotoxin production by the p21ras-raf-MEK-ERK cascade in PHA/PMA-stimulated Jurkat cells. Journal of Immunology 162:3316-20.

Hii CS, Huang ZH, Bilney A, Costabile M, Murray AW, Rathjen DA, Der CJ, Ferrante A. 1998. Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases. Journal of Biological Chemistry 273:19277-82.

I am able to provide media comment in the following areas of expertise:

Discipline: Immunology