Dr Sheridan Gentili
|Position:||Senior Lecturer in Biological Sciences|
|Division/Portfolio:||Division of Health Sciences|
|School/Unit:||School of Pharmacy and Medical Sciences|
|Campus:||City East Campus|
|Telephone:||+61 8 830 22452|
|Fax:||+61 8 830 22389|
|URL for Business Card:||http://people.unisa.edu.au/Sheridan.Gentili|
Dr Sheridan Gentili has a background in physiology with a focus on the early origins of metabolic health. She graduated from her Ph.D. in 2006 from the University of Adelaide, and commenced as Lecturer in Biological Science in 2007, coordinating both Molecules to Tissues A and B. In 2014 Dr Gentili was awarded the UniSA Citation for Outstanding Contribution to Student Learning. Dr Gentili's research focuses on the impact that diets high in carbohydrates have on the development of metabolic disorders and whether dietary interventions could play a role in alleviating such effects. Dr Gentili has recently commenced a Graduate Diploma in Biostatistics through the Biostatistics Collaboration of Australia.
- I have an interest in teaching Physiology and Biology, with an interest in maternal and fetal nutrition, and metabolism.
|BIOL 1007||Molecules to Tissues A|
|BIOL 1012||Molecules to Tissues B|
|BIOL 1051||Physiology Essentials 100|
|BIOL 1050||Human Physiology 101|
|BIOL 2052||Lifespan Physiology|
The Higher Education Research and Development Society of Australasia: HERDSA
Society for Gynecologic Investigation: SGI
International Society for Developmental Origins of Health and Disease: DOHaD
Healthy Development Adelaide: HDA
Ph.D. (The University of Adelaide)
Graduate Diploma in Biostatistics (BCA via The University of Adelaide, commenced in 2015)
B.Sc. (Hons) (The University of Adelaide)
B.Sc. (Flinders University)
- My research is focused on determining the metabolic health of the neonate, specifically insulin sensitivity, and the pathways associated with the development of non-alcoholic fatty liver disease and fat deposition as a result of high carbohydrate exposure before birth. Current projects are examining the impact of sugar-sweetened beverages during pregnancy and lactation on the offspring, and the effects of either a high vs low glycaemic index diet in an established rodent model.
Gugusheff JR, Sim P, Kheng A, Gentili S, Al-Nussairawi M, Brand-Miller J, Muhlhausler BS (2015) The effect of maternal and post-weaning low and high glycaemic index diets on glucose tolerance, fat deposition and hepatic function in rat offspring. Journal of Developmental Origins of Health and Disease, 10:1-10.
Toop CR, Muhlhausler BS, O'Dea K, Gentili S (2015) Consumption of sucrose, but not high fructose corn syrup, leads to increased adiposity and dyslipidaemia in the pregnant and lactating rat. Journal of Developmental Origins of Health and Disease, 6(1):38-46.
Regnault TR, Gentili S, Sarr O, Toop CR, Sloboda DM (2013) Fructose, pregnancy and later life impacts. Clinical and Experimental Pharmacology and Physiology, 40: 824–837
Gentili S, Toop CR (2013) The impact of maternal sucrose and high fructose corn syrup consumption during pregnancy on the rat offspring. Journal of the Society for Gynecologic Investigation, Orlando, USA, 2013, pp 135A
Posterino GS, Dunn SL, Botting KJ, Wang W, Gentili S, Morrison JL (2011) Changes in cardiac troponins with gestational age explain changes in cardiac muscle contractility in the sheep fetus. Journal of Applied Physiology 111(1):236-243
Micke GC, Sullivan TM, McMillen IC, Gentili S, Perry VEA (2011) Heifer nutrient intake during early- and mid-gestation programs adult offspring adiposity and mRNA expression of growth-related genes in adipose depots. Reproduction 141(5):697-706
Micke GC, Sullivan TM, Gentili S, McMIllen IC and Perry VEA (2011) Protein intake during gestation affects postnatal bovine skeletal muscle growth and relative expression of IGF1, IGF1R, IGF2 and IGF2R. Molecular and Cellular Endocrinology 332(1-2):234-241
Morrison JL, Duffield JA, Muhlhausler BS, Gentili S, McMillen IC. (2010) Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity. Pediatr Nephrol. 25(4):669-77
Gentili S, Morrison JL, McMillen IC (2009) Intrauterine Growth Restriction and Differential Patterns of Hepatic Growth and Expression of IGF1, PCK2, and HSDL1 mRNA in the Sheep Fetus in Late Gestation. Biology of Reproduction 80(6):1121-1127
McMillen IC, Rattanatray L, Duffield JA, Morrison JL, MacLaughlin SM, Gentili S, Muhlhausler BS (2009) The Early Origins of Later Obesity: Pathways and Mechanisms. Advances in Experimental Medicine and Biology 646:71-81
McMillen IC, MacLaughlin SM, Muhlhausler BS, Gentili S, Duffield JA, Morrison JS (2008) Developmental origins of adult health and disease: The role of periconceptional and fetual nutrition. Basic & Clinical Pharmacology & Toxicology 102(2):82-9.
Gentili S, Morrison JL, McMillen IC (2007) Expression of hypoxia inducible factor (HIF) 1alpha, 1beta and IGF2 in the adrenal, liver and lung of the chronically hypoxic fetal sheep. Reproductive Sciences, Nevada, USA, 14 (Supplement):129A
MacLaughlin SM, Walker SK, Kleemann DO, Sibbons JP, Tosh DN, Gentili S, Coulter CL, McMillen IC (2007) Impact of periconceptional undernutrition on the adrenal growth and adrenal IGF and steroidogenic enzyme expression in the sheep fetus during early pregnancy. Endocrinology 148(4):1911-1920
Hyatt M, Gopalakrishnan GS, Bispham J, Gentili S, McMillen IC, Rhind SM, Rae MT, Kyle CE, Brooks AN, Jones C, Budge H, Walker D, Stephenson T, Symonds ME (2007) Maternal nutrient restriction in early pregnancy programmes hepatic mRNA expression of growth hormone prolactin and insulin-like growth factor-II receptors hepatocyte growth factor Bax suppressor of cytokine signalling-3 and liver size in the adult male. Journal of Endocrinology 192:87-97
Gentili S, Schwartz J, Waters MJ, McMillen IC (2006) Prolactin and the expression of suppressor of cytokine signaling-3 (SOCS-3) in the sheep adrenal before birth. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 291:R1399-R1405
Gentili S, Waters MJ, McMillen IC 2006 Differential regulation of Suppressor of Cytokine Signaling-3 (SOCS-3) in the liver and adipose tissue of the sheep fetus in late gestation. American Journal of Physiology 290:R1044-R1051
MacLaughlin SM, Muhlhausler BS, Gentili S, McMillen IC 2006 When in gestation do nutritional alterations exert their effects? A focus on the early origins of adult disease. Current Opinion in Endocrinology and Diabetes 13:516-522
Gentili S, Waters MJ, McMillen IC (2005) Tissue specific expression of suppressor of cytokine signalling (SOCS)-3 during fetal development. FASEB Journal, San Diego, USA, 2005, pp A742-A742
Gentili S, Schwartz J, Waters MJ, McMillen IC (2005) The fetal adrenal is a novel prolactin target: Prolactin stimulates expression of suppressor of cytokine signalling-3 (SOCS-3) in the fetal adrenal during late gestation. Journal of the Society for Gynecologic Investigation, Los Angeles, USA, 2005, pp 178A-179A
Maternal low GI diets for improving metabolic outcomes in the offspring
|Opportunities for Honours and Ph.D. student level projects exist for the following project area. This project involves the use of established molecular techniques to understand the impact that low GI diet during pregnancy has on the offspring. This project is being conducted in collaboration with colleagues at The University of Adelaide.|
|Opportunities for Honours and Ph.D. student level projects exist for the following project area. This project involves the use of established molecular techniques to understand the impact that a maternal diet high in sugar has on the health of the offspring.|
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