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Dr Sheridan Gentili 

Position: Senior Lecturer in Biological Sciences Dr Sheridan Gentili
Division/Portfolio: Division of Health Sciences
School/Unit: School of Pharmacy and Medical Sciences
Campus: City East Campus
Office: P5-31
Telephone: +61 8 830 22452
Fax: +61 8 830 22389
Email: Sheridan_dot_Gentili_at_unisa_dot_edu_dot_au
URL for Business Card: http://people.unisa.edu.au/Sheridan.Gentili
(Sheridan Gentili is currently on leave - last day on leave is Monday, 22 September 2014)


Dr Sheridan Gentili has a background in physiology with a focus on the early origins of metabolic health. She graduated from her Ph.D. in 2006 from the University of Adelaide, and commenced as Lecturer in Biological Science in 2007, coordinating both Biological Science 100 and 101. Sheridan’s research focuses on the impact that diets high in carbohydrates have on the development of metabolic disorders and whether dietary interventions could play a role in alleviating such effects.


Links to other sites



Research Page - School of Pharmacy and Medical Science


Google Scholar


LinkedIn Homepage


The Young Investigator Award


Teaching interests

  • I have an interest in teaching Physiology and Biology, with an interest in maternal and fetal nutrition, and metabolism.

I teach the following courses

BIOL 1007Molecules to Tissues A
BIOL 1012Molecules to Tissues B
BIOL 1050Human Physiology 101
BIOL 2052Lifespan Physiology and Biochemistry


Professional associations

Society for Gynecologic Investigation: SGI

International Society for Developmental Origins of Health and Disease: DOHaD

Healthy Development Adelaide: HDA


Qualifications

Ph.D. (The University of Adelaide)

B.Sc. (Hons) (The University of Adelaide)

B.Sc. (Flinders University)


Research interests

  • My research is focused on determining the metabolic health of the neonate, specifically insulin sensitivity, and the pathways associated with the development of non-alcoholic fatty liver disease and fat deposition as a result of high carbohydrate exposure before birth. Current projects are examining the impact of sugar-sweetened beverages during pregnancy and lactation on the offspring, and the effects of either a high vs low glycaemic index diet in an established rodent model.

Research publications

Regnault TR, Gentili S, Sarr O, Toop CR, Sloboda DM (2013) Fructose, pregnancy and later life impacts. Clinical and Experimental Pharmacology and Physiology, 40: 824–837

Gentili S, Toop CR (2013) The impact of maternal sucrose and high fructose corn syrup consumption during pregnancy on the rat offspring. Journal of the Society for Gynecologic Investigation, Orlando, USA, 2013, pp 135A

Posterino GS, Dunn SL, Botting KJ, Wang W, Gentili S, Morrison JL (2011) Changes in cardiac troponins with gestational age explain changes in cardiac muscle contractility in the sheep fetus. Journal of Applied Physiology 111(1):236-243

Micke GC, Sullivan TM, McMillen IC, Gentili S, Perry VEA (2011) Heifer nutrient intake during early- and mid-gestation programs adult offspring adiposity and mRNA expression of growth-related genes in adipose depots. Reproduction 141(5):697-706

Micke GC, Sullivan TM, Gentili S, McMIllen IC and Perry VEA (2011) Protein intake during gestation affects postnatal bovine skeletal muscle growth and relative expression of IGF1, IGF1R, IGF2 and IGF2R. Molecular and Cellular Endocrinology 332(1-2):234-241

Morrison JL, Duffield JA, Muhlhausler BS, Gentili S, McMillen IC. (2010) Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity. Pediatr Nephrol. 25(4):669-77

Gentili S, Morrison JL, McMillen IC (2009) Intrauterine Growth Restriction and Differential Patterns of Hepatic Growth and Expression of IGF1, PCK2, and HSDL1 mRNA in the Sheep Fetus in Late Gestation. Biology of Reproduction 80(6):1121-1127

McMillen IC, Rattanatray L, Duffield JA, Morrison JL, MacLaughlin SM, Gentili S, Muhlhausler BS (2009) The Early Origins of Later Obesity: Pathways and Mechanisms. Advances in Experimental Medicine and Biology 646:71-81

McMillen IC, MacLaughlin SM, Muhlhausler BS, Gentili S, Duffield JA, Morrison JS (2008) Developmental origins of adult health and disease: The role of periconceptional and fetual nutrition. Basic & Clinical Pharmacology & Toxicology 102(2):82-9.

Gentili S, Morrison JL, McMillen IC (2007) Expression of hypoxia inducible factor (HIF) 1alpha, 1beta and IGF2 in the adrenal, liver and lung of the chronically hypoxic fetal sheep. Reproductive Sciences, Nevada, USA, 14 (Supplement):129A

MacLaughlin SM, Walker SK, Kleemann DO, Sibbons JP, Tosh DN, Gentili S, Coulter CL, McMillen IC (2007) Impact of periconceptional undernutrition on the adrenal growth and adrenal IGF and steroidogenic enzyme expression in the sheep fetus during early pregnancy. Endocrinology 148(4):1911-1920

Hyatt M, Gopalakrishnan GS, Bispham J, Gentili S, McMillen IC, Rhind SM, Rae MT, Kyle CE, Brooks AN, Jones C, Budge H, Walker D, Stephenson T, Symonds ME (2007) Maternal nutrient restriction in early pregnancy programmes hepatic mRNA expression of growth hormone prolactin and insulin-like growth factor-II receptors hepatocyte growth factor Bax suppressor of cytokine signalling-3 and liver size in the adult male. Journal of Endocrinology 192:87-97

Gentili S, Schwartz J, Waters MJ, McMillen IC (2006) Prolactin and the expression of suppressor of cytokine signaling-3 (SOCS-3) in the sheep adrenal before birth. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 291:R1399-R1405

Gentili S, Waters MJ, McMillen IC 2006 Differential regulation of Suppressor of Cytokine Signaling-3 (SOCS-3) in the liver and adipose tissue of the sheep fetus in late gestation. American Journal of Physiology 290:R1044-R1051

MacLaughlin SM, Muhlhausler BS, Gentili S, McMillen IC 2006 When in gestation do nutritional alterations exert their effects? A focus on the early origins of adult disease. Current Opinion in Endocrinology and Diabetes 13:516-522

Gentili S, Waters MJ, McMillen IC (2005) Tissue specific expression of suppressor of cytokine signalling (SOCS)-3 during fetal development. FASEB Journal, San Diego, USA, 2005, pp A742-A742

Gentili S, Schwartz J, Waters MJ, McMillen IC (2005) The fetal adrenal is a novel prolactin target: Prolactin stimulates expression of suppressor of cytokine signalling-3 (SOCS-3) in the fetal adrenal during late gestation. Journal of the Society for Gynecologic Investigation, Los Angeles, USA, 2005, pp 178A-179A


Research Degree Supervisor

Students who may be interested in Honours or Ph.D. study in the projects listed here should contact me for further details.

Current Projects:

Maternal low GI diets for improving metabolic outcomes in the offspring
 Opportunities for Honours and Ph.D. student level projects exist for the following project area. This project involves the use of established molecular techniques to understand the impact that low GI diet during pregnancy has on the offspring. This project is being conducted in collaboration with colleagues at The University of Adelaide.
The adverse effects of maternal sugar consumption on the metabolic health of the offspring
 Opportunities for Honours and Ph.D. student level projects exist for the following project area. This project involves the use of established molecular techniques to understand the impact that a maternal diet high in sugar has on the health of the offspring.




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